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Symbol
Name
ID 		Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
MGI:97255
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Unroofed coronary sinus
Atrial septal defect
Primum atrial septal defect
Secundum atrial septal defect
Sinus venosus atrial septal defect
Left ventricular hypertrophy
Right ventricular dilatation
Mitral valve prolapse
Left ventricular noncompaction
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Cardiomegaly
Stroke
Reduced left ventricular ejection fraction
Severely reduced left ventricular ejection fraction
Increased left ventricular end-diastolic volume
Left ventricular outflow tract obstruction
Systolic heart murmur
Aortic regurgitation
Pulmonary arterial hypertension
Absent P wave
Shortened PR interval
Prolonged QRS complex
Prolonged QT interval
Prolonged QTc interval
Right axis deviation
Sick sinus syndrome
Sinus bradycardia
Cardiac arrest
Sudden cardiac death
Palpitations
Atrial fibrillation
Paroxysmal atrial fibrillation
Atrial flutter
Ventricular tachycardia
Torsade de pointes
Ventricular escape rhythm
Ventricular fibrillation
Ventricular preexcitation
Ventricular preexcitation with multiple accessory pathways
Wolff-Parkinson-White syndrome
Atrioventricular block
Right bundle branch block
Congestive heart failure
Syncope
Disease(s) Associated with MYH6
atrial heart septal defect
atrial heart septal defect 3
dilated cardiomyopathy 1EE
hypertrophic cardiomyopathy 14
sick sinus syndrome
Wolff-Parkinson-White syndrome

Mouse Phenotypes
cardiovascular system phenotype
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
increased myocardial fiber size
myocardial fiber disarray
calcified myocardium
disorganized myocardium
myocardium hypertrophy
myocardium necrosis
heart left ventricle hypertrophy
abnormal heart morphology
abnormal heart atrium morphology
increased heart atrium size
dilated heart atrium
increased heart weight
cardiac hypertrophy
abnormal heart ventricle morphology
abnormal heart left ventricle morphology
decreased heart left ventricle wall thickness
dilated heart left ventricle
thick ventricular wall
cardiac fibrosis
cardiac interstitial fibrosis
dilated cardiomyopathy
dystrophic cardiac calcinosis
abnormal cardiovascular system physiology
decreased cardiac output
decreased cardiac stroke volume
decreased cardiac muscle contractility
decreased ventricle muscle contractility
increased cardiac muscle contractility
abnormal cardiac muscle relaxation
abnormal heart echocardiography feature
abnormal heart ventricle pressure
decreased left ventricle diastolic pressure
decreased left ventricle systolic pressure
irregular heartbeat
abnormal myocardial fiber physiology
increased cardiomyocyte apoptosis
cardiomyopathy
Availability Mouse Genotype
Myh6tm1.1Jpsc/Myh6tm1.1Jpsc *
Myh6tm1Ces/Myh6tm1Ces
Myh6tm1Jse/Myh6tm1Jse
Myh6tm2Ces/Myh6tm2Ces
Myh6tm2Jse/Myh6tm2Jse
Myh6tm3.1Jse/Myh6tm3.1Jse
Myh6tm1.1Jpsc/Myh6+ *
Myh6tm1.1Jpsc/Myh6tm2Jse
Myh6tm1Ces/Myh6+
Myh6tm1Jse/Myh6+
Myh6tm1Rbns/Myh6+
Myh6tm2Ces/Myh6+
Myh6tm2Jse/Myh6+
Myh6tm3.1Jse/Myh6+
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory